TANOVEA-CA1 Canine Lymphoma Treatment Delivers Excellent Results for Stella

 

Earlier this year, the team at NorthStar VETS in New Jersey shared the story of Stella in a guest post to the VetDC blog. Stella had been diagnosed with canine lymphoma in March 2017. She nearly completed two cycles of conventional chemotherapy when the cancer once again began to progress.

Looking for another way to address the disease, Jennifer Kim, DVM, DACVIM (Oncology) decided to try a protocol using TANOVEA-CA1 (rabacfosadine for injection), the first FDA conditionally approved drug for the treatment of lymphoma in dogs. One week after Stella received treatment, her cancer was in remission with no reported side effects.

 

 

An Optimistic Outlook Following TANOVEA-CA1 Treatment

Given the rapid return of Stella’s cancer following her initial response to conventional chemotherapy treatment, her owners were wondering if they would see the same outcome with TANOVEA-CA1. We are pleased to report that NorthStar VETS recently contacted us to say that Stella continues to be happy, healthy and full of energy following her course of TANOVEA-CA1 treatment.

While there is no guarantee that all dogs will have the same experience as Stella, her case is another example of the potential for positive results through the use of this novel cancer-fighting drug, which:

  • Accumulates in rapidly dividing lymphoma cells and kills them
  • Produced a 77% overall response rate in clinical testing
  • Has demonstrated responses both in dogs new to treatment and those who are not responding to conventional chemotherapy
  • Is administered in one dose every three weeks for a total of only five treatment visits

To learn more about TANOVEA-CA1, visit www.vet-dc.com/tanovea or talk with your veterinarian.

 

Important Safety Information: TANOVEA®-CA1 is indicated for the treatment of lymphoma in dogs. In clinical trials, the most frequently reported adverse reactions included decreased white blood cell count, diarrhea, vomiting, decreased or loss of appetite, weight loss, decreased activity level, and skin problems. Serious and sometimes fatal respiratory complications, including pulmonary fibrosis have occurred in dogs treated with TANOVEA-CA1. Do not use in West Highland White Terriers and use with caution in other terrier breeds. Owners should take extra care when handling and cleaning up after their dog for five days after treatment. Please see the package insert for full prescribing information, warnings and precautions.

34 Comments

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  1. Hi – my 8yr old beagle Lilley has been snoring and breathing louder than usual – we thought possibly just pollen and was given antibiotics and a pill for allergies. 10 days later, not much better and seems to have swelling around her neck – took back to vet, they did an x-ray and felt lump under neck and small ones behind her legs – said she had Lymphoma, no blood test etc. Should she get a blood test to make sure what we are dealing with? They gave her predisone and her breathing is quiet, even being a “tad” overweight! Her appetite has not changed, she seems the same as always. We are in the Richmond Va area – have you any suggestions or help???

    • Hello PJ, I’m so sorry to hear about what Lilley is going through, though glad to hear that she is getting some relief with the prednisone. To answer your question about having diagnostics done, yes, Lilley should definitely have a definitive diagnosis of lymphoma before she is started on lymphoma treatment. You mentioned a blood test specifically… while there are often changes to the blood in lymphoma patients, and blood tests should be run before starting treatment to check for adequate organ function, what is needed to definitively diagnose lymphoma is microscopic examination of the cells from the affected lymph nodes. The sample is usually obtained by fine needle aspirate (the veterinarian would stick a needle into one of the lymph nodes, then shoot the cells inside the needle onto a slide for examination with a microscope). It’s actually a very easy procedure and most dogs tolerate it well. Some veterinarians prefer to surgically excise a portion of an affected lymph node and have it examined.
      I would strongly recommend that you seek the advice of a veterinary oncologist or veterinary internist. There are many options for treating lymphoma and you should have all of those options explained to you. I am happy to help you find a specialist in your area, and will email you some options in/around the Richmond area. Please let me know after you receive the list if there is anything else I can do to help, and I wish you and your girl the best of luck in your fight against lymphoma.


  2. Our Dog James was diagnosed with Leukemia or Lymphoma – they don’t know exactly which, mid-April. He is well advanced in his stages. End of April was given several blood transfusions and started on Prednisone. Sunday he started declining again and we were advised he needs more blood transfusions and only has 1-2 weeks to live. He was given 1.5 transfusion last night because that was all they had on hand. Would TANOVEA-CA1 work for him? We live in Las Vegas, NV. The only oncologist here is rude and didn’t even bother to keep our scheduled appointment. He left 15min after our scheduled appt. time and never came into the room. We had to seek out other animal hospitals to find a treatment and that’s when he was placed on prednisone.

    • Hello Pam,

      I’m so sorry to hear about what you, James, and your family are going through. He is a lucky boy to have a family so dedicated to his care. I’m also very sorry to hear that you have not had a good experience with the oncologist in your area.

      TANOVEA-CA1 can be used to treat the various types of lymphoma that occur in dogs, but it is not labeled for use in the treatment of leukemia. Unfortunately, I don’t know if TANOVEA-CA1 would be a treatment option for James since they have not been able to provide you with a clear diagnosis.

      I know that I am not providing any concrete answers for you and I am sorry. It sounds like you are doing everything possible to look at the options available for his treatment. If you are able to seek a consultation with an internal medicine specialist or a different oncologist, I would encourage you to do so. One option is to contact the oncology department at Colorado State University’s Flint Animal Cancer Center and request a consultation. There is an online service for making the request, I’ll paste the link below. I wish you all the best in the time you have with James. I’m sorry I can’t be of greater help.

      https://www.csuanimalcancercenter.org/consult-service


  3. My sweet baby boy Dexter is just over 8 years old and is a basset hound/lab mix. He recently underwent and completed the CHOP protocall at a MED VET clinic in Mandeville, LA. Almost 6 months to the day after completing treatment we were informed on April 17, 2019 that the cancer had returned. CHOP was very expensive and we were left with the option of repeating the CHOP program , oral chemo which was to be administered every three weeks until the drug was no longer effective (also very expensive because of his weight 47KG) or the prednisone which he now taking. I like the idea of only five treatments and this drug, TANOVEA, was never presented to as an option. Can you please guide me to someone in my area. Can’t even begin to express my heartache and sorrow for my beloved Dexter. Thank you in advance!

    • I am so sorry to hear about Dexter, I know it’s a hard road to be facing with a beloved family member. I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  4. Hi, my dog is Bucky and was hewas diagnosed today with Lymphoma at the VCA in Los Angeles, CA….took him in due to shaking (or tremors) …blood tests showed too high calcium…did a biopsy on a swollen gland and it came back 90% chance it was lymphoma…he is on prednisone now , a muscle relaxor, and a diuretic to try to lower the calcium. Would love to talk to a doctor who knows about Tanovea in the West Los Angeles, CA area. Chemotherapy is do damaging to the body and I was told that there was no guarantee Chemo would kill the cancer cells. No sure how much chemo costs but my Nationwide insurance does cover $2400 for the chemo…is that good or bad?

    • Hello Barbara – I’m so sorry to hear that Bucky has been diagnosed with lymphoma. It’s a difficult diagnosis to face with a beloved friend. Thanks for reaching out for information about TANOVEA-CA1. I just emailed you with some information about practices that use TANOVEA-CA1. Please let me know if there is anything else I can do to help you.


  5. Hi my lab Buddy was diagnosed with lymphoma today stage 2…my boy is 12. The vet gave him prednisone to help for the next couple months but said eventually it will spread and we will need to make a decision. I need another opinion. Chemo was not recommended because of his age. And it’s quite costly. I need to know if this Tanovea is an option and is it cost effective? We love our Buddy so much.

    • I’m very sorry to hear about Buddy’s diagnosis. Have you considered consulting with a veterinary oncologist about the options that exist? If you can tell me where you are located, I can help direct you to a specialist in your area. Also, we are conducting our pivotal trial, and an additional clinical trial, and have several sites across the US. I may be able to direct you to one of those sites if you are located in their vicinity.

      As for Buddy’s age, we don’t assign any age as a cutoff for being a good candidate for treatment. Rather, we look at the overall state of health and wellbeing. If Buddy is still feeling relatively good, is eating, and behaving normally, he may be a good candidate for treatment.

      Unfortunately, chemotherapy is not inexpensive. TANOVEA-CA1 tends to be similar in cost to other protocols like CHOP. An oncologist can discuss your options, though, as there might be something suitable for Buddy.

      I’m sorry I can’t be of more help, but please let me know where you are located if you would like additional information about specialists and/or trials.

      • And also Buddy is still active. He still likes to play fetch and he eats and drinks as normal. He’s a little slower and has to rest more frequently but he is still very much a puppy at heart. He also walks and runs with a limp now due to one of the lumps being in his shoulder.

        • That’s great to hear that Buddy is still youthful, be sure to let your veterinarian know that he’s eating and drinking as normal. Tell them everything that you told us about Buddy and they will be able to help you determine the next steps regarding treatment. We wish both you and Buddy the best.

      • Thank you. Yes, we are located in Culpeper, Virginia.

        • Hi Christina – I just emailed you the names and contact information for several specialists in your area. Please let me know if there is anything else we can do to help!


  6. Our poodle is 4 years old, and developed very swollen glands in neck and groin areas. Took him to vet who diagnosed cancer immediately. Went home and started research on Bcell Lymphoma, which was confirmed by tests. Found info on Tanovia-CA1, and continued researching treatments. Started treatment at Blue Pearl Vet. Clinic near me. After talking to Dr., reviewing treatments, we chose to start with Tanovia as choice to treat.
    After 1st treatment symptoms were mild: tiredness, nausea but controlled with meds, some diaarhea, but feeling better by 3rd day. In checkup, one week later, our dog had no swollen glands showing, and seemed to feel like playing again. The vet said his blood tests showed normal!

    This week is his second treatment. My question is do you recommend continuing treatments for the 5 doses, if results show normal blood tests after treatment? I realize Lymphoma can return. I also saw where you can retreat with Tanovia-CA1. Is the recommended 5 doses based on test results, or a standard based on best studies for most animals?

    • First and foremost, I am so sorry to hear that your dog has lymphoma – but I am so glad to hear that he is doing well on TANOVEA-CA1. The side effects you described are very common during treatment, and I’m glad to hear he recovered from those effects and is feeling more like himself.

      As to your question about the number of treatments, the label directions (which must be adhered to per federal law due to the conditional labeling) state “once every three weeks for up to five doses”. The reason we recommend five doses is that, historically, five doses of a single-agent chemotherapy protocol has been deemed most appropriate/successful for the treatment of lymphoma. For example, doxorubicin used alone, and lomustine used alone, are both administered for five treatments as a full course. I would suggest that you discuss this with the treating oncologist/veterinarian. They can help you decide how you want to move forward, but our recommendation is to complete all five treatments if the drug is being tolerated by the patient.


  7. My American Bulldog was just diagnosed with lymphoma. It seems to be progressing rapidly. Is Tanozea an option? We live in Hughesville MD.

    • Hello Kim – I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  8. I am also looking for veterinary clinics, That offer this treatment, Allentown Pa is the area. Please get back to me with this information. Thank you, Dale Gehring

    • Hello Dale – I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  9. Does Tanovea work well in both t and b cell?

    • Hello Mary –
      Thank you for your inquiry. Tanovea-CA1 data from the reasonable expectation of effectiveness section of our product insert supports the use in both B and T cell lymphoma. As with other cytotoxic therapies used in lymphoma, treatment response rates and durations in T-cell patients are typically lower than those seen in B-cell patients. In the 22 dogs evaluated for the conditional approval, there was a 100% overall
      response rate (complete and partial responders) in naïve dogs and a 64% overall response
      rate in refractory dogs. Please let us know if there is anything else we can do to assist you.


  10. Looking for vets in the Lafayette, IN area that offer this treatment

    • Hello Chris. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  11. Our dog was dianoised with lymphoma. Can you please tell me if there are any doctors in Detroit suburbs that offer this treatment?

    • Hello Nichole –
      I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  12. Our 10 year old chow has been diagnosed with Lymphoma. Not sure what type yet. Is it available in the Detroit suburb area? Thank you.

    • I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  13. Our Basset was recently diagnosed w/lymphoma and undergoing chemotherapy, however we’d be interested in pursuing this alternative. Is it available in the Rochester NY area? Thank you

    • I am very sorry to hear of your Basset’s diagnosis. I just emailed you some information about a veterinary clinic in your area that uses TANOVEA-CA1. Please let me know if there is anything else I can do to assist you.


  14. Please email me where I can find a vet in Miami Florida that have this vaccine ASAP my mini pincher was diagnose With this type of cancer

    • Hello Shairoon –
      I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  15. Please email me where to find a vet that has this asap. I in BREAUX Bridge, La.

    • Hi Robert, we will be emailing you shortly regarding veterinary clinics near you that could administer TANOVEA-CA1.