TANOVEA-CA1 Canine Lymphoma Treatment Delivers Excellent Results for Stella

 

Earlier this year, the team at NorthStar VETS in New Jersey shared the story of Stella in a guest post to the VetDC blog. Stella had been diagnosed with canine lymphoma in March 2017. She nearly completed two cycles of conventional chemotherapy when the cancer once again began to progress.

Looking for another way to address the disease, Jennifer Kim, DVM, DACVIM (Oncology) decided to try a protocol using TANOVEA-CA1 (rabacfosadine for injection), the first FDA conditionally approved drug for the treatment of lymphoma in dogs. One week after Stella received treatment, her cancer was in remission with no reported side effects.

 

 

An Optimistic Outlook Following TANOVEA-CA1 Treatment

Given the rapid return of Stella’s cancer following her initial response to conventional chemotherapy treatment, her owners were wondering if they would see the same outcome with TANOVEA-CA1. We are pleased to report that NorthStar VETS recently contacted us to say that Stella continues to be happy, healthy and full of energy following her course of TANOVEA-CA1 treatment.

While there is no guarantee that all dogs will have the same experience as Stella, her case is another example of the potential for positive results through the use of this novel cancer-fighting drug, which:

  • Accumulates in rapidly dividing lymphoma cells and kills them
  • Produced a 77% overall response rate in clinical testing
  • Has demonstrated responses both in dogs new to treatment and those who are not responding to conventional chemotherapy
  • Is administered in one dose every three weeks for a total of only five treatment visits

To learn more about TANOVEA-CA1, visit www.vet-dc.com/tanovea or talk with your veterinarian.

 

Important Safety Information: TANOVEA®-CA1 (rabacfosadine for injection) is not for use in humans and should be kept out of the reach of children. Wear chemotherapy-resistant gloves to prevent contact with feces, urine, vomit, and saliva of treated dogs for five days following treatment. Rabacfosadine is cytotoxic and can cause birth defects and affect female and male fertility. Pregnant and breast-feeding women should not prepare or administer the product. Serious and sometimes fatal respiratory complications, including pulmonary fibrosis have occurred in dogs treated with TANOVEA®-CA1. Do not use in dogs with pulmonary fibrosis, a history of chronic pulmonary disease that could lead to fibrosis, or in breeds with a predisposition to this condition such as West Highland White Terriers. Use with caution in other terrier breeds. Do not use in dogs that are pregnant, lactating, or intended for breeding. Most common adverse reactions included diarrhea, neutropenia, hyporexia, weight loss, and lethargy.  Please see the package insert for full prescribing information.

58 Comments

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  1. Hi,
    My 5.5 year old boxer boy has been diagnosed with T-Cell Lymphoma on Sep 1,2019 and his CHOP chemo is starting this week. He is currently on Prednisone and node have shrunk a bit. This drug Tanovea look promising. So my question should I wait to see the impact of CHOP chemo or we can try this even early on. Please let us know what to discuss with my vet ?
    Thanks Mohit

    • Hello Mohit –

      I am very sorry to hear about your dog’s recent diagnosis of lymphoma, I know it is a frightening road to have to go down with a beloved family member. Because we are not a veterinary consulting service and have not examined your dog, we are not able to advise you about the type of chemotherapy to choose. Only your veterinarian or a veterinary oncologist can help guide that decision. They likely have a rationale for choosing the protocol they have, but you can ask them to discuss the options with you so that you understand why they are making specific recommendations. I wish you and your dog the best moving forward with treatment.


  2. My pup Gretchen was diagnosed with Tcell lymphoma on 11/30/18 and started chemo (CHOP with doxorubicin) on 12/11/18 completing 6 rounds of treatment. She had a very short remission (maybe 4 weeks) and has been thru several drugs including Prednisone, Prednisolone, Vincristine, Cyclophosphomide, Lomustine, Mitoxantrone, Asparaginase, Procarbazine. She is on several supplements to support immunity. Her nodes are still enlarged and she had her first Tanovea treatment on 8/26/19. I am interested in using CBD Oil in addition or replacement of the chemo drugs but am concerned about conflicts. I can not get any input from veterinarians on the subject – it’s an unknown. Can you point me in the right direction of knowledgeable folks please? Or let me know if there are any contraindications to pursue the CBD option? Thank you.

    • I’m very sorry to hear about Gretchen’s diagnosis of lymphoma, it sounds like she is quite a fighter and is lucky to have someone so dedicated to her care. Unfortunately, there is really nothing we can tell you in regards to CBD oil. It is in the very early stages of research in veterinary oncology (I believe at least one university vet school is conducting studies with it). I would recommend that you search the AVMA Animal Health Studies Database to see if you can find any information about current CBD oil studies, and if you find anything, contact the site where it is being studied to see if they can provide you with information. TANOVEA-CA1 has not been studied in combination with CBD oil, so we do not have any safety or efficacy data on their concomitant use. I’m sorry I can’t be of more help. I wish you and Gretchen the best.


  3. Hi: My Ajax was diagnosed with lymphoma on April 19, 2019, and began the CHOP protocol. On July 26th, he presented enlarged lymph nodes again and is now undergoing CCNU therapy. I’m in the Boston area and interested in knowing more about Tanovea. Can you provide further information, along with a facility that would know more about and provide this treatment? Thank you.

    • Please see your email for a message I just sent. Thank you.


  4. Our rescue sharpei, Tori (we are not sure how old she is), was diagnosed with b cell lymphoma stage Vb in January 2018. Tori was started on L-CHOP in January 2018 and obtained a partial remission. She was switched to CCNU and had stable disease. On March 14, 2018 she received her first dose of Tanovea. She was deemed to be in a complete remission on 4/25/18. She received her final dose of Tanovea on 6/6/18. She is still doing great and had her last check up 7/11/19. Don’t give up hope–I feel our girl is a poster child for Tanovea and its effectiveness!

    • Hello Victoria –
      Thank you so much for sharing your story about Tori. We genuinely appreciate ALL updates about TANOVEA-CA1 patients, and hearing such a great success story is wonderful. I hope Tori continues to stay in remission for a long time so that you and your family can continue to enjoy many more tail-wagging days with her!


  5. My 9 yo husky/ collie mix, Tawny, has been diagnosed with Lymphoma. She has enlarged lymph nodes in her neck and behind her rear knees. Why had blood and apirate of the neck nodes confirming diagnosis. She is also hypothyroid, which is well under control with medication and blood test confirmed not map levels. We want to do eve we can to keep her with us as long as her quality of life permits. She has an appointment to take another sample, to be sent to Colorado for an oncologist to tell us what kind of treatment would be best for her. I would like some info on this drug, so I can discuss it with our vet. Wish us luck! We are not giving up until we have no choice! We plan on having our girl with us for a long time. Thanks

    • I am so sorry to hear what you and Tawny are going through. I just emailed several pdf documents about TANOVEA-CA1 to you to review and also to share with your veterinarian. Please let me know if you have any questions or need any additional information about veterinarians in your area that use TANOVEA-CA1. I wish you and Tawny the best in her battle against lymphoma.


  6. Hello, my nine year old cattle dog/lab mix was diagnosed with lymphoma 4 weeks and 2 days ago. Vet gave her 4-6 weeks. Although she does appear to be deteriorating she is still happy as a clam at the pool, has a great appetitive, and still has good energy. We’ve done no treatments other than some holistic and CBD. I noticed her breathing had gotten bad the last couple of days but the vet said she wasn’t concerned, although also said she likely only had about another week based on the rapid growth of all her tumors. I’d love to know more about this drug. I’m based in AZ. Thanks!

    • Hello Gabrielle – I just emailed you some information. Please feel free to reach out again if you have any additional questions. Thank you.


  7. My 9 year old rottweiler was diagnosed with intestinal Lymphoma in November 2018. Since December 4th, she has been on the Vincristine/CCNU combo, which thankfully eliminated the mass within 3-4 treatments. At month 6, we are now exploring alternative protocols due to her severe lack of appetite and food aversion. In conjunction with the chemotherapy, she also receives weekly acupuncture treatments, Chinese herbs, and K9 Immunity Plus supplements.
    Please email me additional information that I can review with my veterinarian oncologist (SAGE Veterinary Hospital, Concord, CA). I’m hoping we can find an alternative treatment that has less side-effects for our girl. Thank you in advance!

    • Hello Jennifer – Please check your email as I just sent you a reply. Thank you.


  8. My 2 year old bullmastiff was diagnosed with a high grade lymphoma that was compressing her spinal cord resulting in back leg weakness. She has been otherwise healthy. She underwent neurosurgery on 21 May to debulk the tumor. Because of the location in the CNS, most chemotherapy agents will not penetrate and her oncologist has chosen a protocol of CCNU and prednisone. Would Tanovea be an option for her? We live in Hampton Roads, VA and there is only one board certified vet oncologist in area.

    • Hello Gail – Please check your email as I just sent you some information. Thank you.


  9. My Molly had been diagnosed with B cell lymphoma. She had her first CHOP protocol injection last Tuesday first For a couple of days she did not want to eat Dr had prescribed netronidazole after a day or so she started eating again and seemed good. Her second treatment was this past Tuesday. When they did her blood her white cell count was too low so they never gave her the treatment and we went home. Since her visit on Tuesday she had lost her appetite so she is not eating, threw up many times in one day and has direahia. The Dr felt it’s not from the chemo treatment as the first shot was done over a week ago. Can you give me any advice as to what it can be from? And your thoughts. Thank you

    • Hello Mary –

      I’m very sorry to hear about Molly’s diagnosis of lymphoma, and also that she is having difficulty since starting chemotherapy. I would encourage you to sit down with your regular veterinarian or a veterinary specialist (oncology or internal medicine) and discuss the problems Molly is having. We are not able to make any recommendations, only a veterinarian that has examined your dog can do that, but they might be able to offer you some suggestions/thoughts about what is going on. The unfortunate thing is that it is not uncommon to see vomiting and diarrhea in relation to chemotherapy, and also due to the disease itself in some cases. Your veterinarian will be able to help figure out how to make Molly more comfortable and, hopefully, suffer fewer clinical signs of illness.


  10. Our 5yr old German Shepherd retriever mix was diagnosed with Lymphoma Nov 2018, he has been on the Wisconsin Madison treatment plan and doing fantastic. Last week was suppose to be his finally treatment however the dr found traces of Lymphoma when tested. We would love more information about this drug. Tango is like our child and we aren’t ready to give up on him.

    • Hello Tiffany –

      I’m very sorry to hear about Tango’s relapse. I just emailed some information to you, please let me know if you have any questions, or if there is anything else we can do to assist you.


  11. Good morning. May 31, 2019. My sweet Rhodesian Ridgeback Nhirra is 7 years old, and she was diagnosed with Lymphoma yesterday. Biopsy results pending. I live in pretty much the middle of no where. Riverton, wyoming. I am lucky to have a husband/wife vet team that are very progressive! As i am in the human health field, I knew to do my own research. I did not want to do the CHOP or protocols like it. I took the info on Tanovea to my vet immediately and got on the phone with our Area Vet School. Colarado State University. They were a big help, as their site is actually doing a clinical trial . Vet ordered drugs today, and hopefully can get it started early next week!! I am really thankful I came across this Drug. I was not going to do anything long and expensive and time intensive, ( I just couldn’t for many reasons) So if this wasn’t an option, I was just going to Prednisone and love her til the end. I’m really hoping this will give us some more time. Can i post our journey thru this process? Thank you, Jane Healy

    • Hello Jane –
      I’m very sorry to hear about Nhirra’s recent diagnosis of lymphoma, but I am so glad to hear that CSU was able to help guide you and your veterinarian in treating her with TANOVEA-CA1. We’d love to hear how she does with treatment. I wish you the very best and hope you have many more good days with her!


  12. Hi – my 8yr old beagle Lilley has been snoring and breathing louder than usual – we thought possibly just pollen and was given antibiotics and a pill for allergies. 10 days later, not much better and seems to have swelling around her neck – took back to vet, they did an x-ray and felt lump under neck and small ones behind her legs – said she had Lymphoma, no blood test etc. Should she get a blood test to make sure what we are dealing with? They gave her predisone and her breathing is quiet, even being a “tad” overweight! Her appetite has not changed, she seems the same as always. We are in the Richmond Va area – have you any suggestions or help???

    • Hello PJ, I’m so sorry to hear about what Lilley is going through, though glad to hear that she is getting some relief with the prednisone. To answer your question about having diagnostics done, yes, Lilley should definitely have a definitive diagnosis of lymphoma before she is started on lymphoma treatment. You mentioned a blood test specifically… while there are often changes to the blood in lymphoma patients, and blood tests should be run before starting treatment to check for adequate organ function, what is needed to definitively diagnose lymphoma is microscopic examination of the cells from the affected lymph nodes. The sample is usually obtained by fine needle aspirate (the veterinarian would stick a needle into one of the lymph nodes, then shoot the cells inside the needle onto a slide for examination with a microscope). It’s actually a very easy procedure and most dogs tolerate it well. Some veterinarians prefer to surgically excise a portion of an affected lymph node and have it examined.
      I would strongly recommend that you seek the advice of a veterinary oncologist or veterinary internist. There are many options for treating lymphoma and you should have all of those options explained to you. I am happy to help you find a specialist in your area, and will email you some options in/around the Richmond area. Please let me know after you receive the list if there is anything else I can do to help, and I wish you and your girl the best of luck in your fight against lymphoma.


  13. Our Dog James was diagnosed with Leukemia or Lymphoma – they don’t know exactly which, mid-April. He is well advanced in his stages. End of April was given several blood transfusions and started on Prednisone. Sunday he started declining again and we were advised he needs more blood transfusions and only has 1-2 weeks to live. He was given 1.5 transfusion last night because that was all they had on hand. Would TANOVEA-CA1 work for him? We live in Las Vegas, NV. The only oncologist here is rude and didn’t even bother to keep our scheduled appointment. He left 15min after our scheduled appt. time and never came into the room. We had to seek out other animal hospitals to find a treatment and that’s when he was placed on prednisone.

    • Hello Pam,

      I’m so sorry to hear about what you, James, and your family are going through. He is a lucky boy to have a family so dedicated to his care. I’m also very sorry to hear that you have not had a good experience with the oncologist in your area.

      TANOVEA-CA1 can be used to treat the various types of lymphoma that occur in dogs, but it is not labeled for use in the treatment of leukemia. Unfortunately, I don’t know if TANOVEA-CA1 would be a treatment option for James since they have not been able to provide you with a clear diagnosis.

      I know that I am not providing any concrete answers for you and I am sorry. It sounds like you are doing everything possible to look at the options available for his treatment. If you are able to seek a consultation with an internal medicine specialist or a different oncologist, I would encourage you to do so. One option is to contact the oncology department at Colorado State University’s Flint Animal Cancer Center and request a consultation. There is an online service for making the request, I’ll paste the link below. I wish you all the best in the time you have with James. I’m sorry I can’t be of greater help.

      https://www.csuanimalcancercenter.org/consult-service


  14. My sweet baby boy Dexter is just over 8 years old and is a basset hound/lab mix. He recently underwent and completed the CHOP protocall at a MED VET clinic in Mandeville, LA. Almost 6 months to the day after completing treatment we were informed on April 17, 2019 that the cancer had returned. CHOP was very expensive and we were left with the option of repeating the CHOP program , oral chemo which was to be administered every three weeks until the drug was no longer effective (also very expensive because of his weight 47KG) or the prednisone which he now taking. I like the idea of only five treatments and this drug, TANOVEA, was never presented to as an option. Can you please guide me to someone in my area. Can’t even begin to express my heartache and sorrow for my beloved Dexter. Thank you in advance!

    • I am so sorry to hear about Dexter, I know it’s a hard road to be facing with a beloved family member. I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  15. Hi, my dog is Bucky and was hewas diagnosed today with Lymphoma at the VCA in Los Angeles, CA….took him in due to shaking (or tremors) …blood tests showed too high calcium…did a biopsy on a swollen gland and it came back 90% chance it was lymphoma…he is on prednisone now , a muscle relaxor, and a diuretic to try to lower the calcium. Would love to talk to a doctor who knows about Tanovea in the West Los Angeles, CA area. Chemotherapy is do damaging to the body and I was told that there was no guarantee Chemo would kill the cancer cells. No sure how much chemo costs but my Nationwide insurance does cover $2400 for the chemo…is that good or bad?

    • I am also in LA and have my 6 yr old rottweiler diagnosed yesterday. Ease share any local oncologist recommendations and what you decided to do/ how it’s going!

      • Hello Larissa – I just emailed you with some information. Please let us know if there is anything else we can do to help.

    • Hello Barbara – I’m so sorry to hear that Bucky has been diagnosed with lymphoma. It’s a difficult diagnosis to face with a beloved friend. Thanks for reaching out for information about TANOVEA-CA1. I just emailed you with some information about practices that use TANOVEA-CA1. Please let me know if there is anything else I can do to help you.


  16. Hi my lab Buddy was diagnosed with lymphoma today stage 2…my boy is 12. The vet gave him prednisone to help for the next couple months but said eventually it will spread and we will need to make a decision. I need another opinion. Chemo was not recommended because of his age. And it’s quite costly. I need to know if this Tanovea is an option and is it cost effective? We love our Buddy so much.

    • I’m very sorry to hear about Buddy’s diagnosis. Have you considered consulting with a veterinary oncologist about the options that exist? If you can tell me where you are located, I can help direct you to a specialist in your area. Also, we are conducting our pivotal trial, and an additional clinical trial, and have several sites across the US. I may be able to direct you to one of those sites if you are located in their vicinity.

      As for Buddy’s age, we don’t assign any age as a cutoff for being a good candidate for treatment. Rather, we look at the overall state of health and wellbeing. If Buddy is still feeling relatively good, is eating, and behaving normally, he may be a good candidate for treatment.

      Unfortunately, chemotherapy is not inexpensive. TANOVEA-CA1 tends to be similar in cost to other protocols like CHOP. An oncologist can discuss your options, though, as there might be something suitable for Buddy.

      I’m sorry I can’t be of more help, but please let me know where you are located if you would like additional information about specialists and/or trials.

      • And also Buddy is still active. He still likes to play fetch and he eats and drinks as normal. He’s a little slower and has to rest more frequently but he is still very much a puppy at heart. He also walks and runs with a limp now due to one of the lumps being in his shoulder.

        • That’s great to hear that Buddy is still youthful, be sure to let your veterinarian know that he’s eating and drinking as normal. Tell them everything that you told us about Buddy and they will be able to help you determine the next steps regarding treatment. We wish both you and Buddy the best.

      • Thank you. Yes, we are located in Culpeper, Virginia.

        • Hi Christina – I just emailed you the names and contact information for several specialists in your area. Please let me know if there is anything else we can do to help!


  17. Our poodle is 4 years old, and developed very swollen glands in neck and groin areas. Took him to vet who diagnosed cancer immediately. Went home and started research on Bcell Lymphoma, which was confirmed by tests. Found info on Tanovia-CA1, and continued researching treatments. Started treatment at Blue Pearl Vet. Clinic near me. After talking to Dr., reviewing treatments, we chose to start with Tanovia as choice to treat.
    After 1st treatment symptoms were mild: tiredness, nausea but controlled with meds, some diaarhea, but feeling better by 3rd day. In checkup, one week later, our dog had no swollen glands showing, and seemed to feel like playing again. The vet said his blood tests showed normal!

    This week is his second treatment. My question is do you recommend continuing treatments for the 5 doses, if results show normal blood tests after treatment? I realize Lymphoma can return. I also saw where you can retreat with Tanovia-CA1. Is the recommended 5 doses based on test results, or a standard based on best studies for most animals?

    • First and foremost, I am so sorry to hear that your dog has lymphoma – but I am so glad to hear that he is doing well on TANOVEA-CA1. The side effects you described are very common during treatment, and I’m glad to hear he recovered from those effects and is feeling more like himself.

      As to your question about the number of treatments, the label directions (which must be adhered to per federal law due to the conditional labeling) state “once every three weeks for up to five doses”. The reason we recommend five doses is that, historically, five doses of a single-agent chemotherapy protocol has been deemed most appropriate/successful for the treatment of lymphoma. For example, doxorubicin used alone, and lomustine used alone, are both administered for five treatments as a full course. I would suggest that you discuss this with the treating oncologist/veterinarian. They can help you decide how you want to move forward, but our recommendation is to complete all five treatments if the drug is being tolerated by the patient.


  18. My American Bulldog was just diagnosed with lymphoma. It seems to be progressing rapidly. Is Tanozea an option? We live in Hughesville MD.

    • Hello Kim – I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  19. I am also looking for veterinary clinics, That offer this treatment, Allentown Pa is the area. Please get back to me with this information. Thank you, Dale Gehring

    • Hello Dale – I just emailed you with some information. Please let us know if there is anything else we can do to assist you.


  20. Does Tanovea work well in both t and b cell?

    • Hello Mary –
      Thank you for your inquiry. Tanovea-CA1 data from the reasonable expectation of effectiveness section of our product insert supports the use in both B and T cell lymphoma. As with other cytotoxic therapies used in lymphoma, treatment response rates and durations in T-cell patients are typically lower than those seen in B-cell patients. In the 22 dogs evaluated for the conditional approval, there was a 100% overall
      response rate (complete and partial responders) in naïve dogs and a 64% overall response
      rate in refractory dogs. Please let us know if there is anything else we can do to assist you.


  21. Looking for vets in the Lafayette, IN area that offer this treatment

    • Hello Chris. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  22. Our dog was dianoised with lymphoma. Can you please tell me if there are any doctors in Detroit suburbs that offer this treatment?

    • Hello Nichole –
      I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  23. Our 10 year old chow has been diagnosed with Lymphoma. Not sure what type yet. Is it available in the Detroit suburb area? Thank you.

    • I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  24. Our Basset was recently diagnosed w/lymphoma and undergoing chemotherapy, however we’d be interested in pursuing this alternative. Is it available in the Rochester NY area? Thank you

    • I am very sorry to hear of your Basset’s diagnosis. I just emailed you some information about a veterinary clinic in your area that uses TANOVEA-CA1. Please let me know if there is anything else I can do to assist you.


  25. Please email me where I can find a vet in Miami Florida that have this vaccine ASAP my mini pincher was diagnose With this type of cancer

    • Hello Shairoon –
      I am very sorry to hear of your dog’s recent diagnosis. I just emailed you some information about veterinary clinics in your area that use TANOVEA-CA1. Please let us know if there is anything else we can do to assist you.


  26. Please email me where to find a vet that has this asap. I in BREAUX Bridge, La.

    • Hi Robert, we will be emailing you shortly regarding veterinary clinics near you that could administer TANOVEA-CA1.