How does TANOVEA®-CA1 work?

TANOVEA®-CA1 is the first lymphoma treatment for dogs that has been conditionally approved by the FDA. Targeting rapidly multiplying lymphoma cells, it mimics a DNA building block, preventing cells from dividing and ultimately causing them to die. The medication is convenient (requiring just five office visits) and generally well tolerated. In clinical trials, 77 percent of dogs with lymphoma responded to treatment with TANOVEA-CA1, even those that had stopped responding to other medications. Watch our video below to learn more about the treatment.

 

Watch on YouTube https://youtu.be/F9HjspUEkyA


  1. My dog had first dose of Tanovea almost 3 weeks ago and is due for her second dose. First dose significantly decreased nodes but the last few days they’ve started to enlarge again. Can it be that the 2nd dose knocks them down completely or is this a sign that it won’t work?

    • Please check your email for a reply to your inquiry.


  2. My 9y 3mo male Brittany spaniel has relapsed with his lymphoma. Unfortunately, we were not able to “type” his lymphoma due to steroids, but believe he is b-cell based on how he responded to first course of CHOP per his vet. He was diagnosed after enlarging lymph nodes in 05/2020, responded with partial remission on Elspar, then full remission with first CHOP treatment. Remained in full remission for one year. Lymph nodes returned and developed a secondary mass in his abdomen near his buttocks, causing straining with bowel movements. Partial response to restarting doxorubicin and Cytoxan. Switched to mitoxantrone with continued growth, second Elspar worked to shrink tumor only by 20%. He remains happy and energetic. We just started Tanovea on Thursday (approximately 4 days ago now). Any idea when we can expect to see him straining less with bowel movements if it is working? He is on lactulose for softening stools, but thus far has had some diarrhea as a side-effect so a bit hard to tell in regards to tumor size on the butt…as straining isn’t an issue currently (no other real side-effects).

    Thanks!


  3. My 6y 3 mo old intact female (never has been/never will be pregnant, lactating, breeding & not around any other dogs) diagnosed w B-cell lymphoma May 2020. Went into remission for about 8 months with CHOPP. Came out of remission with her heat cycle (which also seemed to “disappear” during treatment with CHOP?) about 2 months after last CHOP treatment. Slow progression with one round of CHOP “sister” drugs. 30% increase with MOPP! 3 areas of lymph nodes are involved, but not every area. Had first Tanovea IV last week. Some bloody diarrhea on Day 6, but seemed to resolve with a Metronidazole pill. Significant decrease in lymph node sizes after 1 week, but all still swollen. Starting Prednizone today (hasn’t has it in about a year). What should I expect in terms of how and how well the Tanovea might work? Will her “intactness” have any impact?
    I also am starting her on new vitamins, probiotics, and am adding other supplements like curcumin and choline. Do any of these (or other similar supplements) interact with Tanovea/prednisone–positively or negatively, or would they simply help the rest of her body with no direct connection to the Tanovea/prednisone?
    Thanks!

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  4. My rescue has stage 4 lymphoma and did not tolerate the CHOP treatment. Lumostine and prednisone have stopped working after 5 months. We are now going to try the Tenovia. Could you tell me
    1. What is the maximum time period for remission that I can expect if the drug is successful?
    2. What percentage of dogs who were no longer responding to other chemo responded favorably to Tenovia?

    Thank you

    • Hello Karen –
      Please check your email for a reply to your post.


  5. This is a longer message to include specifics.
    Female 7 yr old English Setter. At 6 yr 2mos, diagnosed with “B” cell Lymphoma. She responded to the U of W CHOP treatment extremely well. The Vincristine, first in the dosage protocol, really knocked the swelling right down within just a few days. Within a month of completeion she has swollen Lymph nodes again though. The Oncologist waited for 2 mos befor starting another protocol. By then the swelling was very profound, So she started CCNU which only kept the swelling static for several wks then swelling began increasing including her Spleen. After switching to Tanovea, within just a few days her Lymph nodes and Spleen were shrunken nearly to normal. At Tanovea treatment #3 the Oncologist saw increase in Lymph node size. I failed to say anything to the Oncologist, but her Lymph nodes shrunk very considerably right after each treatment, but by the next therapy they had begun to enlarge, then they would shrink. The Oncologist only saw the result at the end of each treatment period which looked like it was just holding static. At the 3rd treatment, the clinic pushed our appointment date out an additional 5 days which gave the swelling a lot more time to increase. Upon seeing an increase in size the Oncologist took my beloved off Tanovea and put her on LOPP. BUT, in consultation, over the phone due to Wuhan Coronavirus, he asked “me” if I wanted to stay on the Tanovea. I was dumbstruck. Why would he be asking me, I thought? I said “your the specialist here”. So he switched to LOPP. We had to wait for the Pharmacy in New Jersey to send the new treatment to my residence and more time elapsed allowing the progression of Lymphoma. The LOPP did not work, so he switched her to Elspar, which did not work, so then went to Palladia. It didn’t work either. So, after another date switch, to another 5 days beyond our scheduled appointment date, trying to coach me to end it, he said he’d exhausted just about everything he had. Then asked if I wanted to try Tanovea again. I said yes please. It has only been 3 days, but I do not see any difference at all. What would you expect at this point? The Tanovea was working befor, but the Oncologist didn’t see the change that I did, and in discussion I believe he had mistakenly removed her from Tanovea, but I don’t know if the succession I witnessed was a good one or if it was showing that Tanovea was not acting normally. At least not as expected. I have no experience with any of this and wonder if we are going to experience any reversal or static or just what. It still dumbfounds me to be asked what I want to do, I am not the professional on this subject and therefor not the subject matter expert. May I have your candid opinion. My beloved is not having much of a life, but she is holding. Thank you Ben Cresswell


  6. Hi, my 8 yo Cavachon has GI lymphoma. She has had CHOP, and then Lomustine. She was doing really well with the Lomustine until last week. After a week of not eating a lot and diarrhea. She had an ultrasound and we found out the lymphoma has spread further in her abdominal area and liver. We just had her treatment on May 21, 2020. It is now May 24th and her diarrhea finally stopped, but she will not eat. Is 3 days too soon to see any improvements? Just not sure of the time frame before she would begin to feel better. Thank you

    • Please check your email for a response to your inquiry.


  7. Does it take a few rounds of Tanovea to see a response? We just finished the second round on our boxer and the lymph nodes are still swollen. It could be a sign she is not responding and the cancer is progressing. She goes back for her third round of Tanovea in three weeks.

    • Hello Danielle –

      I’m sorry to hear about your boxer’s diagnosis, lymphoma is a tough battle to face with a beloved member of your family.

      Typically, responses to TANOVEA-CA1 are seen fairly quickly following the first administration. Based on data from the clinical studies used to support a reasonable expectation of effectiveness, median time to maximal response was between 7 and 21 days, depending on the study design (these are the earliest time points where response was documented, i.e. the earliest recheck time point). Anecdotally, we have seen responses quicker than that in some patients but no statistics exist because the earliest recheck point for patients in our studies was 7 days.

      I would recommend you discuss the situation with the treating veterinarian to have them determine if continuing TANOVEA-CA1 is the most appropriate path, or if there are other treatment options to consider. I’m sorry I can’t be of more help.


  8. We saw a specialist recommened and this was never mentioned!!!!!

    • We’re sorry that Tanovea CA-1 was not an option for you. Each veterinarian has a different selection of treatments for various conditions that they offer, we are working to make Tanovea CA-1 an option for treating lymphoma at every veterinary clinic in the country.


  9. How fast does it start to work? Our dog gets his first treatment tomorrow. His lymphnodes under his mandible are huge and he is starting to have a hard time swallowing. How soon after that first dose, if he responds, does the swelling start to decrease?

    • Sorry to hear about your pup. We will respond via email with additional information, but typically, dogs respond within 7 days of treatment. That being said, every case is different – some dogs have taken much longer to demonstrate noticeable responses – however, you should see something within the next 3 weeks. Your veterinarian will be in the best position to assess, so please keep them in the loop.
      Best wishes for a successful outcome!


  10. I have a Carolina Dog that is 11 years old. She has Mast Cell Tumorss, and now we have just discovered a very large lump under her collar, and the vet feels that it is Lymphoma. Considering the fact that she has Mast Cell Tumors ( 2 surgerys, removing 3 tumors), would you recommend this treatment, or with Mast Cell as well would it not work? We like any other dog owner love her with all our hearts, Please advise if you can help us, Please.

    • So sorry to hear about your pup. We will reach out directly via email.


  11. How is Tanovea adminstered?

    • It is administered via a 30 minute intravenous infusion, once every three weeks


  12. SO COOL , AWESOME GOD CREATION