How does TANOVEA®-CA1 work?

TANOVEA®-CA1 is the first lymphoma treatment for dogs that has been conditionally approved by the FDA. Targeting rapidly multiplying lymphoma cells, it mimics a DNA building block, preventing cells from dividing and ultimately causing them to die. The medication is convenient (requiring just five office visits) and generally well tolerated. In clinical trials, 77 percent of dogs with lymphoma responded to treatment with TANOVEA-CA1, even those that had stopped responding to other medications. Watch our video below to learn more about the treatment.


Watch on YouTube


Please provide us with the following before posting a comment

  1. Does it take a few rounds of Tanovea to see a response? We just finished the second round on our boxer and the lymph nodes are still swollen. It could be a sign she is not responding and the cancer is progressing. She goes back for her third round of Tanovea in three weeks.

    • Hello Danielle –

      I’m sorry to hear about your boxer’s diagnosis, lymphoma is a tough battle to face with a beloved member of your family.

      Typically, responses to TANOVEA-CA1 are seen fairly quickly following the first administration. Based on data from the clinical studies used to support a reasonable expectation of effectiveness, median time to maximal response was between 7 and 21 days, depending on the study design (these are the earliest time points where response was documented, i.e. the earliest recheck time point). Anecdotally, we have seen responses quicker than that in some patients but no statistics exist because the earliest recheck point for patients in our studies was 7 days.

      I would recommend you discuss the situation with the treating veterinarian to have them determine if continuing TANOVEA-CA1 is the most appropriate path, or if there are other treatment options to consider. I’m sorry I can’t be of more help.

  2. We saw a specialist recommened and this was never mentioned!!!!!

    • We’re sorry that Tanovea CA-1 was not an option for you. Each veterinarian has a different selection of treatments for various conditions that they offer, we are working to make Tanovea CA-1 an option for treating lymphoma at every veterinary clinic in the country.

  3. How fast does it start to work? Our dog gets his first treatment tomorrow. His lymphnodes under his mandible are huge and he is starting to have a hard time swallowing. How soon after that first dose, if he responds, does the swelling start to decrease?

    • Sorry to hear about your pup. We will respond via email with additional information, but typically, dogs respond within 7 days of treatment. That being said, every case is different – some dogs have taken much longer to demonstrate noticeable responses – however, you should see something within the next 3 weeks. Your veterinarian will be in the best position to assess, so please keep them in the loop.
      Best wishes for a successful outcome!

  4. I have a Carolina Dog that is 11 years old. She has Mast Cell Tumorss, and now we have just discovered a very large lump under her collar, and the vet feels that it is Lymphoma. Considering the fact that she has Mast Cell Tumors ( 2 surgerys, removing 3 tumors), would you recommend this treatment, or with Mast Cell as well would it not work? We like any other dog owner love her with all our hearts, Please advise if you can help us, Please.

    • So sorry to hear about your pup. We will reach out directly via email.

  5. How is Tanovea adminstered?

    • It is administered via a 30 minute intravenous infusion, once every three weeks